Outlooks on Epstein-Barr virus associated gastric cancer.

Naseem, Madiha; Barzi, Afsaneh; Brezden-Masley, Christine; Puccini, Alberto; Berger, Martin Dave; Tokunaga, Ryuma; Battaglin, Francesca; Soni, Shivani; McSkane, Michelle; Zhang, Wu; Lenz, Heinz-Josef (2018). Outlooks on Epstein-Barr virus associated gastric cancer. Cancer treatment reviews, 66, pp. 15-22. Elsevier 10.1016/j.ctrv.2018.03.006

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Epstein-Barr virus associated gastric cancer (EBVaGC) comprises approximately 10% of gastric carcinomas. Multiple factors contribute to tumorigenesis, including EBV driven hypermethylation of tumor suppressor genes, inflammatory changes in gastric mucosa, host immune evasion by EBV and changes in cell cycle pathways. The unique molecular characteristics of EBVaGC, such as programmed death ligand 1 (PD-L1) overexpression, highlight the potential for using EBV as a biomarker for response to immunotherapy. Few studies have reported benefit from immunotherapy in EBV positive cancers, and clinical trials investigating the impact of checkpoint inhibitors in EBVaGC are currently underway. This review provides the most recent updates on molecular pathophysiology, epidemiology, clinical features and treatment advances pertaining to EBVaGC.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Berger, Martin Dave

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1532-1967

Publisher:

Elsevier

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

28 Feb 2019 14:27

Last Modified:

27 Oct 2019 10:41

Publisher DOI:

10.1016/j.ctrv.2018.03.006

PubMed ID:

29631196

Uncontrolled Keywords:

Biomarker EBV Gastric cancer Immunotherapy PD-L1 Viruses

BORIS DOI:

10.7892/boris.124095

URI:

https://boris.unibe.ch/id/eprint/124095

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