Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease.

Ghersi-Egea, Jean-François; Strazielle, Nathalie; Catala, Martin; Silva-Vargas, Violeta; Doetsch, Fiona; Engelhardt, Britta (2018). Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease. Acta neuropathologica, 135(3), pp. 337-361. Springer-Verlag 10.1007/s00401-018-1807-1

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The barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the choroid plexuses. At the interface between two circulating fluids, these richly vascularized veil-like structures display a peculiar morphology explained by their developmental origin, and fulfill several functions essential for CNS homeostasis. They form a neuroprotective barrier preventing the accumulation of noxious compounds into the CSF and brain, and secrete CSF, which participates in the maintenance of a stable CNS internal environment. The CSF circulation plays an important role in volume transmission within the developing and adult brain, and CSF compartments are key to the immune surveillance of the CNS. In these contexts, the choroid plexuses are an important source of biologically active molecules involved in brain development, stem cell proliferation and differentiation, and brain repair. By sensing both physiological changes in brain homeostasis and peripheral or central insults such as inflammation, they also act as sentinels for the CNS. Finally, their role in the control of immune cell traffic between the blood and the CSF confers on the choroid plexuses a function in neuroimmune regulation and implicates them in neuroinflammation. The choroid plexuses, therefore, deserve more attention while investigating the pathophysiology of CNS diseases and related comorbidities.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health








Ursula Zingg-Zünd

Date Deposited:

25 Feb 2019 17:06

Last Modified:

25 Feb 2019 17:13

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Blood-brain barrier Blood-cerebrospinal fluid barrier Brain development Choroid plexus Inflammation Lymphocyte Stem cell Tight junction Transporters




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