Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model.

Locatelli, Giuseppe; Theodorou, Delphine; Kendirli, Arek; Jordão, Marta Joana Costa; Staszewski, Ori; Phulphagar, Kshiti; Cantuti-Castelvetri, Ludovico; Dagkalis, Athanasios; Bessis, Alain; Simons, Mikael; Meissner, Felix; Prinz, Marco; Kerschensteiner, Martin (2018). Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nature neuroscience, 21(9), pp. 1196-1208. Nature America 10.1038/s41593-018-0212-3

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Mononuclear phagocytes are key regulators of both tissue damage and repair in neuroinflammatory conditions such as multiple sclerosis. To examine divergent phagocyte phenotypes in the inflamed CNS, we introduce an in vivo imaging approach that allows us to temporally and spatially resolve the evolution of phagocyte polarization in a murine model of multiple sclerosis. We show that the initial proinflammatory polarization of phagocytes is established after spinal cord entry and critically depends on the compartment they enter. Guided by signals from the CNS environment, individual phagocytes then switch their phenotype as lesions move from expansion to resolution. Our study thus provides a real-time analysis of the temporospatial determinants and regulatory principles of phagocyte specification in the inflamed CNS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Locatelli, Giuseppe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1097-6256

Publisher:

Nature America

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

25 Feb 2019 15:54

Last Modified:

05 Dec 2022 15:24

Publisher DOI:

10.1038/s41593-018-0212-3

PubMed ID:

30127427

BORIS DOI:

10.7892/boris.124105

URI:

https://boris.unibe.ch/id/eprint/124105

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