Oral Versus Intragastric Inoculation: Similar Pathways of Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response.

Barreto de Albuquerque, Juliana; Silva Dos Santos, Danielle; Stein, Jens Volker; de Meis, Juliana (2018). Oral Versus Intragastric Inoculation: Similar Pathways of Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response. Frontiers in immunology, 9, p. 1734. Frontiers Research Foundation 10.3389/fimmu.2018.01734

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Currently, oral infection is the most frequent transmission mechanism of Chagas disease in Brazil and others Latin American countries. This transmission pathway presents increased mortality rate in the first 2 weeks, which is higher than the calculated mortality after the biting of infected insect vectors. Thus, the oral route of infection, and the consequences in the host must be taken into account when thinking on the mechanisms underlying the natural history of the disease. Distinct routes of parasite entry may differentially affect immune circuits, stimulating regional immune responses that impact on the overall profile of the host protective immunity. Experimental studies related to oral infection usually comprise inoculation in the mouth (oral infection, OI) or gavage (gastrointestinal infection, GI), being often considered as similar routes of infection. Hence, establishing a relationship between the inoculation site (OI or GI) with disease progression and the mounting of -specific regional immune responses is an important issue to be considered. Here, we provide a discussion on studies performed in OI and GI in experimental models of acute infections, including infection.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Barreto de Albuquerque, Juliana and Stein, Jens Volker

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

12 Feb 2019 12:51

Last Modified:

17 Feb 2019 02:42

Publisher DOI:

10.3389/fimmu.2018.01734

PubMed ID:

30100907

Uncontrolled Keywords:

T cell activation Trypanosoma cruzi immune response intragastric infection oral cavity

BORIS DOI:

10.7892/boris.124285

URI:

https://boris.unibe.ch/id/eprint/124285

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