Nonalimental Scurvy With Relapse Symptoms After Stopping Oral Vitamin C Supplementation.

Vaezipour, Nina; Leibundgut, Kurt (2018). Nonalimental Scurvy With Relapse Symptoms After Stopping Oral Vitamin C Supplementation. Pediatrics, 142(2) American Academy of Pediatrics 10.1542/peds.2017-2139

[img] Text
e20172139.full.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Historically linked to sea voyagers in the 18th century, scurvy has become extremely rare during the last century in developed countries. However, it is still present in some at-risk populations and often overlooked in pediatric patients with restricted diets due to behavioral, neurodevelopmental, or psychiatric problems. So far, the only known etiology of developing scurvy is nutritional deficiency of vitamin C. In this report, we describe the case of a 3-year-old previously healthy Swiss girl without any history of previous poor dietary intake, who presented a picture of systemic inflammation including persisting fever, palpable purpura located on the extensor sides of the extremities, refusal to bear weight, and gingival bleeding. Blood tests revealed a significant increase of inflammatory markers and hypoalbuminemia. Full-body MRI revealed symmetrical bone marrow edema consistent with findings in previously reported cases of children with scurvy. After starting a high-dose oral vitamin C supplementation, the patient showed rapid clinical, laboratory, and radiologic improvement, but after stopping the treatment 4 months later, the patient developed relapse symptoms with pronounced fatigue, refusing to walk, and hair loss. These symptoms led us to restart the oral supplementation, which resulted in secondary normalization of her condition. The cause of her symptoms still remains unclear and presents the first case to our knowledge describing scurvy symptoms that are not directly linked to deficient dietary intake.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Vaezipour, Nina and Leibundgut, Kurt

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0031-4005

Publisher:

American Academy of Pediatrics

Language:

English

Submitter:

Karen Lidzba

Date Deposited:

26 Feb 2019 09:12

Last Modified:

26 Feb 2019 09:20

Publisher DOI:

10.1542/peds.2017-2139

PubMed ID:

30065004

BORIS DOI:

10.7892/boris.124291

URI:

https://boris.unibe.ch/id/eprint/124291

Actions (login required)

Edit item Edit item
Provide Feedback