Urinary sex steroid and glucocorticoid hormones are associated with muscle mass and strength in healthy adults

Ackermann, Daniel; Escher, Geneviève; d'Uscio, Claudia Henriette; Grössl, Michael; Vogt, Bruno; Dhayat, Nasser (2019). Urinary sex steroid and glucocorticoid hormones are associated with muscle mass and strength in healthy adults. The journal of clinical endocrinology and metabolism, 104(6), pp. 2195-2215. Oxford University Press 10.1210/jc.2018-01942

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Context Sex steroid hormones exhibit anabolic effects whereas a deficiency engenders sarcopenia. Moreover, supra-physiological levels of glucocorticoids promote skeletal muscle atrophy, while physiologic levels of glucocorticoids may improve muscle performance. Objective To study the relationship between both groups of steroid hormones at a physiological range with skeletal muscle mass and function in the general population. Design Cross-sectional analysis of the associations between urinary excreted androgens, estrogens, glucocorticoids and steroid hormone metabolite ratios with lean mass and handgrip strength in a population-based cohort. Setting Three centers in Switzerland including 1128 participants. Measures Urinary steroid hormone metabolite excretion by GC-MS, lean mass by bioimpedance analysis and isometric handgrip strength by dynamometry. Results For lean mass a strong positive association was found with 11β-OH-androsterone and with most glucocorticoids. Androsterone showed a positive association in middle-aged and older adults. Estriol showed a positive association only in men. For handgrip strength strong positive associations with androgens were found in middle-aged and older adults, whereas positive associations were found with cortisol metabolites in young to middle-aged adults. Conclusions Sex steroid and glucocorticoids are strongly positively associated with skeletal muscle mass and strength in the upper limbs. The associations with muscle strength appear to be independent of muscle mass. Steroid hormones exert age-specific anabolic effects on lean mass and handgrip strength: Deficits in physical performance of aged muscles may be attenuated by androgens, whereas glucocorticoids in a physiological range increase skeletal muscle mass at all ages, and muscle strength in particular in younger adults.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie

UniBE Contributor:

Ackermann, Daniel; Escher, Geneviève; d'Uscio, Claudia Henriette; Grössl, Michael; Vogt, Bruno and Dhayat, Nasser

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1945-7197

Publisher:

Oxford University Press

Language:

English

Submitter:

Nasser Dhayat

Date Deposited:

20 Feb 2019 16:39

Last Modified:

29 Apr 2019 01:31

Publisher DOI:

10.1210/jc.2018-01942

PubMed ID:

30690465

Uncontrolled Keywords:

Skeletal muscle mass; Handgrip strength; age; sex; Sex steroid hormones; Glucocorticoids

BORIS DOI:

10.7892/boris.124604

URI:

https://boris.unibe.ch/id/eprint/124604

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