Multi-day rhythms modulate seizure risk in epilepsy

Baud, Maxime Olivier; Kleen, Jonathan K.; Mirro, Emily A.; Andrechak, Jason C.; King-Stephens, David; Chang, Edward F.; Rao, Vikram R. (2018). Multi-day rhythms modulate seizure risk in epilepsy. Nature communications, 9(1), p. 88. Nature Publishing Group 10.1038/s41467-017-02577-y

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Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. The ability to anticipate seizures would enable preventative treatment strategies. A central but unresolved question concerns the relationship of seizure timing to fluctuating rates of interictal epileptiform discharges (here termed interictal epileptiform activity, IEA), a marker of brain irritability observed between seizures by electroencephalography (EEG). Here, in 37 subjects with an implanted brain stimulation device that detects IEA and seizures over years, we find that IEA oscillates with circadian and subject-specific multidien (multi-day) periods. Multidien periodicities, most commonly 20–30 days in duration, are robust and relatively stable for up to 10 years in men and women. We show that seizures occur preferentially during the rising phase of multidien IEA rhythms. Combining phase information from circadian and multidien IEA rhythms provides a novel biomarker for determining relative seizure risk with a large effect size in most subjects.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Baud, Maxime Olivier

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2041-1723

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Panagiota Milona

Date Deposited:

07 Mar 2019 09:02

Last Modified:

17 Mar 2019 02:36

Publisher DOI:

10.1038/s41467-017-02577-y

PubMed ID:

29311566

BORIS DOI:

10.7892/boris.124633

URI:

https://boris.unibe.ch/id/eprint/124633

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