Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

Classen, G.; Classen, C.; Bernasconi, Corrado Angelo; Brandt, C.; Gold, R.; Chan, Andrew; Hoepner, Robert (2019). Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy. Journal of neurovirology, 25(1), pp. 133-136. Springer 10.1007/s13365-018-0689-2

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Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88) and specificity (82) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bernasconi, Corrado Angelo; Chan, Andrew and Hoepner, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1538-2443

Publisher:

Springer

Language:

English

Submitter:

Panagiota Milona

Date Deposited:

29 Mar 2019 13:34

Last Modified:

23 Oct 2019 14:29

Publisher DOI:

10.1007/s13365-018-0689-2

PubMed ID:

30414049

Uncontrolled Keywords:

Eeg John Cunningham virus encephalopathy Multiple sclerosis Natalizumab Pharmacovigilance Screening

BORIS DOI:

10.7892/boris.124668

URI:

https://boris.unibe.ch/id/eprint/124668

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