Stevens-Johnson Syndrome After Armodafinil Use

Holfinger, S.; Roy, A.; Schmidt, Markus (2018). Stevens-Johnson Syndrome After Armodafinil Use. Journal of clinical sleep medicine, 14(5), pp. 885-887. American Academy of Sleep Medicine 10.5664/jcsm.7132

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ABSTRACT: We present the case of a 21-year-old woman in whom Stevens-Johnson syndrome (SJS) developed after initiation of armodafinil. Although this rare and life-threatening reaction is listed on armodafinil's label, no cases have been reported in the literature. This case, in addition to an update of the drug's label after post-marketing research, both support the link between armodafinil and SJS. Providers should maintain a high clinical suspicion for SJS when starting therapy to minimize associated morbidity and mortality by discontinuing armodafinil at the onset of first symptoms.

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