Cortical abnormalities in episodic migraine: A multi-center 3T MRI study

Magon, S.; May, A.; Stankewitz, A.; Goadsby, P. J.; Schankin, Christoph Josef; Ashina, M.; Amin, F. M.; Seifert, C. L.; Mallar Chakravarty, M.; Muller, J.; Sprenger, T. (2019). Cortical abnormalities in episodic migraine: A multi-center 3T MRI study. Cephalalgia, 39(5), pp. 665-673. Sage Publications 10.1177/0333102418795163

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BACKGROUND: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies. OBJECTIVE: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. METHODS: Three Tesla MRI data of 131 patients (38 with and 93 without aura) and 115 control subjects were analysed. A vertex-wise linear model was applied controlling for age, gender and MRI scanner to investigate differences between groups and determine the impact of clinical factors on cortical thickness measures. RESULTS: Migraineurs showed areas of thinned cortex compared with controls bilaterally in the central sulcus, in the left middle-frontal gyrus, in left visual cortices and the right occipito-temporal gyrus. Frequency of migraine attacks and the duration of the disorder had a significant impact on cortical thickness in the sensorimotor cortex and middle-frontal gyrus. Patients without aura showed thinner cortex than controls bilaterally in the central sulcus and in the middle frontal gyrus, in the left primary visual cortices, in the left supramarginal gyrus and in the right cuneus. Patients with aura showed clusters of thinner cortex bilaterally in the subparietal sulcus (between the precuneus and posterior cingulate cortex), in the left intraparietal sulcus and in the right anterior cingulate. CONCLUSION: These results indicate cortical abnormalities in specific brain regions in migraineurs. Some of the observed abnormalities may reflect a genetic susceptibility towards developing migraine attacks, while others are probably a consequence of repeated head pain attacks.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Schankin, Christoph Josef

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0333-1024

Publisher:

Sage Publications

Language:

English

Submitter:

Panagiota Milona

Date Deposited:

30 Jan 2019 15:33

Last Modified:

19 Apr 2019 01:31

Publisher DOI:

10.1177/0333102418795163

PubMed ID:

30525946

Uncontrolled Keywords:

Migraine brain cortical thickness magnetic resonance imaging

URI:

https://boris.unibe.ch/id/eprint/124730

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