Miclea, A.; Salmen, Anke; Zoehner, G.; Diem, Lara; Kamm, Christian P.; Chaloulos-Iakovidis, Panagiotis; Miclea, M.; Briner, Myriam Sandra; Kilidireas, K.; Stefanis, L.; Chan, Andrew; Evangelopoulos, Maria Eleptheria; Hoepner, Robert (2019). Age-dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross-sectional study. CNS neuroscience & therapeutics, 25(4), pp. 527-531. Blackwell Publishing 10.1111/cns.13083
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INTRODUCTION: Multiple sclerosis (MS) is an autoimmune disease of the CNS, which predominantly affects women. Studies investigating the sex distribution in MS are sparse. We aim to analyze the female-to-male ratio (F/M ratio) in different MS phenotypes in association with age at diagnosis and year of birth. METHODS: We performed a retrospective cross-sectional analysis by cumulating data (sex, year of birth, age at diagnosis, and MS phenotypes) from unpublished and published studies of the participating centers. RESULTS: Datasets of 945 patients were collected. The overall F/M ratio was 1.9:1.0 and female preponderance was present in all phenotypes except for primary progressive MS (PPMS), in which men were predominantly affected (F/M ratio: 0.5:1.0). Female preponderance declined with increasing age at diagnosis and was no longer present in relapsing-remitting MS (RRMS) patients > 58 years of age. CONCLUSION: Our data demonstrate an age dependency of female preponderance in MS except for PPMS. This could be influenced by the lifecycle of sex hormone secretion in women. In PPMS, a male preponderance was observed in all age-groups, which might point to pathophysiological mechanisms being less influenced by sex hormones.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Salmen, Anke, Diem, Lara, Chaloulos-Iakovidis, Panagiotis, Briner, Myriam Sandra, Chan, Andrew Hao-Kuang, Hoepner, Robert |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1755-5930 |
Publisher: |
Blackwell Publishing |
Language: |
English |
Submitter: |
Panagiota Milona |
Date Deposited: |
31 Jan 2019 17:22 |
Last Modified: |
02 Mar 2023 23:31 |
Publisher DOI: |
10.1111/cns.13083 |
PubMed ID: |
30411534 |
Uncontrolled Keywords: |
Multiple sclerosis aging sex distribution sex hormones |
BORIS DOI: |
10.7892/boris.124744 |
URI: |
https://boris.unibe.ch/id/eprint/124744 |
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