Tasks of activities of daily living (ADL) are more valuable than the classical neurological examination to assess upper extremity function and mobility in multiple sclerosis

van Munster, C. E.; D'Souza, M.; Steinheimer, Saskia Marie; Kamm, Christian Philipp; Burggraaff, J.; Diederich, M.; Kravalis, K.; Dorn, J.; Walsh, L.; Dahlke, F.; Kappos, L.; Uitdehaag, B. M. (2019). Tasks of activities of daily living (ADL) are more valuable than the classical neurological examination to assess upper extremity function and mobility in multiple sclerosis. Multiple sclerosis journal, 25(12), pp. 1673-1681. Sage 10.1177/1352458518796690

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BACKGROUND: Accurate clinical assessment in multiple sclerosis (MS) is challenging. The Assess MS system is being developed to automatically quantify motor dysfunction in MS, including upper extremity function (UEF) and mobility. OBJECTIVE: To determine to what extent combinations of standardized movements included in the Assess MS system explain accepted measures of UEF and mobility. METHODS: MS patients were recruited at four European MS centres. Eight movements were selected, including tasks of activities of daily living (ADL) and classical neurological tests. Movements were recorded on video and rated by experienced neurologists ( n = 5). Subsequently, multivariate linear regression models were performed to explain the variance of the Nine-Hole Peg Test (9HPT), Arm Function in Multiple Sclerosis Questionnaire (AMSQ) and Timed-25 Foot Walk test (T25WT). RESULTS: In total, 257 patients were included. The movements explained 62.9 to 80.1 of the variance of the 9HPT models, 43.3 and 44.3 of the AMSQ models and 70.8 of the T25WT. In all models, tasks of ADL contributed most to the variance. CONCLUSION: Combinations of movements are valuable to assess UEF and mobility. Incorporating ADL tasks into daily clinical practice and clinical trials may be more valuable than the classical neurological examination of UEF and mobility.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Steinheimer, Saskia Marie and Kamm, Christian Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1352-4585

Publisher:

Sage

Language:

English

Submitter:

Panagiota Milona

Date Deposited:

25 Mar 2019 17:55

Last Modified:

23 Oct 2019 08:18

Publisher DOI:

10.1177/1352458518796690

PubMed ID:

30168739

Uncontrolled Keywords:

Multiple sclerosis activities of daily living ambulation disability mobility upper extremity function

BORIS DOI:

10.7892/boris.124791

URI:

https://boris.unibe.ch/id/eprint/124791

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