The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism

Bovi, Tommaso; Antonini, Angelo; Ottaviani, Sarah; Antonioli, Angela; Cecchini, Maria Paola; Di Francesco, Vincenzo; Bassetto, Maria Antonietta; Zamboni, Mauro; Fiaschi, Antonio; Moretto, Giuseppe; Sbarbati, Andrea; Osculati, Francesco; Tinazzi, Michele (2010). The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism. Journal of neurology, 257(11), pp. 1882-9. Heidelberg: Springer-Medizin-Verlag 10.1007/s00415-010-5631-3

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Olfactory impairment has been reported in drug-induced parkinsonism (DIP), but the relationship between dopaminergic dysfunction and smell deficits in DIP patients has not been characterized. To this end, we studied 16 DIP patients and 13 patients affected by Parkinson's disease (PD) using the "Sniffin' Sticks" test and [(123)I] FP-CIT SPECT (single-photon emission computed tomography). DIP patients were divided based on normal (n = 9) and abnormal (n = 7) putamen dopamine transporter binding. Nineteen healthy age- and sex-matched subjects served as controls of smell function. Patients with DIP and pathological putamen uptake had abnormal olfactory function. In this group of patients, olfactory TDI scores (odor threshold, discrimination and identification) correlated significantly with putamen uptake values, as observed in PD patients. By contrast, DIP patients with normal putamen uptake showed odor functions-with the exception of the threshold subtest-similar to control subjects. In this group of patients, no significant correlation was observed between olfactory TDI scores and putamen uptake values. The results of our study suggest that the presence of smell deficits in DIP patients might be more associated with dopaminergic loss rather than with a drug-mediated dopamine receptor blockade. These preliminary results might have prognostic and therapeutic implications, as abnormalities in these individuals may be suggestive of an underlying PD-like neurodegenerative process.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Cecchini, Marco Giovanni

ISSN:

0340-5354

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1007/s00415-010-5631-3

PubMed ID:

20635186

Web of Science ID:

000284978800014

URI:

https://boris.unibe.ch/id/eprint/1248 (FactScience: 202402)

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