Uszczynska-Ratajczak, Barbara; Lagarde, Julien; Frankish, Adam; Guigó, Roderic; Johnson, Rory Baldwin (2018). Towards a complete map of the human long non-coding RNA transcriptome. Nature Reviews. Genetics, 19(9), pp. 535-548. Natue Publishing Group 10.1038/s41576-018-0017-y
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Gene maps, or annotations, enable us to navigate the functional landscape of our genome. They are a resource upon which virtually all studies depend, from single-gene to genome-wide scales and from basic molecular biology to medical genetics. Yet present-day annotations suffer from trade-offs between quality and size, with serious but often unappreciated consequences for downstream studies. This is particularly true for long non-coding RNAs (lncRNAs), which are poorly characterized compared to protein-coding genes. Long-read sequencing technologies promise to improve current annotations, paving the way towards a complete annotation of lncRNAs expressed throughout a human lifetime.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Johnson, Rory Baldwin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1471-0056 |
Publisher: |
Natue Publishing Group |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
07 Mar 2019 09:21 |
Last Modified: |
05 Dec 2022 15:25 |
Publisher DOI: |
10.1038/s41576-018-0017-y |
PubMed ID: |
29795125 |
BORIS DOI: |
10.7892/boris.124814 |
URI: |
https://boris.unibe.ch/id/eprint/124814 |
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