The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer.

Tiede, Stefanie; Meyer-Schaller, Nathalie; Kalathur, Ravi Kiran Reddy; Ivanek, Robert; Fagiani, Ernesta; Schmassmann, Philip; Stillhard, Patrick; Häfliger, Simon; Kraut, Norbert; Schweifer, Norbert; Waizenegger, Irene C; Bill, Ruben; Christofori, Gerhard (2018). The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer. Oncogenesis, 7(9), p. 73. Springer Nature 10.1038/s41389-018-0083-1

[img]
Preview
Text
41389_2018_Article_83.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (4MB) | Preview

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that regulates a plethora of downstream signaling pathways essential for cell migration, proliferation and death, processes that are exploited by cancer cells during malignant progression. These well-established tumorigenic activities, together with its high expression and activity in different cancer types, highlight FAK as an attractive target for cancer therapy. We have assessed and characterized the therapeutic potential and the biological effects of BI 853520, a novel small chemical inhibitor of FAK, in several preclinical mouse models of breast cancer. Treatment with BI 853520 elicits a significant reduction in primary tumor growth caused by an anti-proliferative activity by BI 853520. In contrast, BI 853520 exerts effects with varying degrees of robustness on the different stages of the metastatic cascade. Together, the data demonstrate that the repression of FAK activity by the specific FAK inhibitor BI 853520 offers a promising anti-proliferative approach for cancer therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Häfliger, Simon and Bill, Ruben

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2157-9024

Publisher:

Springer Nature

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

08 Mar 2019 10:56

Last Modified:

23 Oct 2019 21:05

Publisher DOI:

10.1038/s41389-018-0083-1

PubMed ID:

30237500

BORIS DOI:

10.7892/boris.124819

URI:

https://boris.unibe.ch/id/eprint/124819

Actions (login required)

Edit item Edit item
Provide Feedback