Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy

Wang, Xuejuan; Fani, Melpomeni; Schulz, Stefan; Rivier, Jean; Reubi, Jean-Claude; Maecke, Helmut R (2012). Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy. European journal of nuclear medicine and molecular imaging, 39(12), pp. 1876-85. Berlin: Springer 10.1007/s00259-012-2231-8

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Targeting of tumours positive for somatostatin receptors (sst) with radiolabelled peptides is of interest for tumour localization, staging, therapy follow-up and targeted radionuclide therapy. The peptides used clinically are exclusively agonists, but recently we have shown that the radiolabelled somatostatin-based antagonist (111)In-DOTA-sst2-ANT may be preferable to agonists. However, a comprehensive study of this radiolabelled antagonist to determine its significance was lacking. The present report describes the evaluation of this novel antagonist labelled with (111)In and (177)Lu in three different tumour models.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1619-7070

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

14 Oct 2019 15:56

Publisher DOI:

10.1007/s00259-012-2231-8

PubMed ID:

22926735

Web of Science ID:

000310950900007

URI:

https://boris.unibe.ch/id/eprint/12488 (FactScience: 218840)

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