Synchronized Oscillations of Arterial Oxygen Saturation, Cerebral Tissue Oxygenation and Heart Rate in Preterm Neonates: Investigation of Long-Term Measurements with Multiple Einstein's Cross Wavelet Analysis.

Scholkmann, Felix; Herrera, Graciela Velasco; Karen, Tanja; Isler, Helene; Ostojic, Daniel; Herrera, Victor Manuel Velasco; Wolf, Ursula; Wolf, Martin (2018). Synchronized Oscillations of Arterial Oxygen Saturation, Cerebral Tissue Oxygenation and Heart Rate in Preterm Neonates: Investigation of Long-Term Measurements with Multiple Einstein's Cross Wavelet Analysis. Advances in experimental medicine and biology, 1072, pp. 157-161. Springer 10.1007/978-3-319-91287-5_25

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BACKGROUND In preterm neonates, the cardiovascular and cerebral vascular control is immature, making the brain vulnerable to an increased incidence of hypoxic and hyperoxic episodes. AIM The aim of the study was to apply the recently developed multiple Einstein's cross wavelet analysis (MECWA) to quantify the coupling of fluctuations of peripherally measured arterial oxygen saturation (SpO), cerebral tissue oxygen saturation (StO) and heart rate (HR). METHODS Two long-term measurements on preterm neonates with a gestational age at birth of 26.4 and 26.8 weeks and a postnatal age of 2.1 and 3.9 weeks were analyzed. MECWA was applied to SpO, StO and HR. RESULTS MECWA showed that the fluctuations of SpO, StO and HR were synchronized in the low-frequency range with periods of ~1 h and ~0.5 h. The amplitudes of the synchronization frequencies were dependent on the individual neonate. DISCUSSION MECWA is a useful novel tool to assess the coupling of physiological signals. The parameters determined by MECWA seem to be related to the chronobiological processes, as well as constant regulations of the cardiovascular and cerebral perfusion state. CONCLUSION MECWA was able to identify long-term synchronization of the cardiovascular and cerebral perfusion state in preterm neonates with periods of ~1 h and ~0.5 h.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

UniBE Contributor:

Scholkmann, Felix and Wolf, Ursula

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0065-2598

Publisher:

Springer

Language:

English

Submitter:

Yasmine Bühlmann

Date Deposited:

02 Sep 2019 07:07

Last Modified:

23 Oct 2019 07:54

Publisher DOI:

10.1007/978-3-319-91287-5_25

PubMed ID:

30178339

BORIS DOI:

10.7892/boris.125003

URI:

https://boris.unibe.ch/id/eprint/125003

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