[Eosinophilic granulocytes-Physiology and pathophysiology].

Sokollik, Christiane; Simon, Hans-Uwe (2019). [Eosinophilic granulocytes-Physiology and pathophysiology]. Zeitschrift für Rheumatologie, 78(4), pp. 306-312. Springer-Medizin-Verlag 10.1007/s00393-018-0574-7

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Eosinophilic granulocytes are a subpopulation of leucocytes and part of the innate immune cell pool. Additionally, they have homeostatic functions in different tissues. Classically, an increased number of eosinophils is associated with allergies and parasitic infections; however, eosinophilia can also be found in vasculitides and malignant tumors. The most important controlling factors of eosinophils are the cytokine interleukin 5 and eotaxins. Eosinophils are able to produce a broad range of signalling factors and toxic proteins, which are stored in cytoplasmic granules and can be quickly and specifically released when needed depending on the stimulus. To combat pathogens, eosinophils can catapult extracellular traps consisting of mitochondrial DNA and toxic proteins into the intercellular space. This review focuses on the basic structure, control and function of eosinophils in health and disease.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Sokollik, Christiane and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-1855

Publisher:

Springer-Medizin-Verlag

Language:

German

Submitter:

Celine Joray

Date Deposited:

30 Jan 2019 11:36

Last Modified:

01 Dec 2020 15:51

Publisher DOI:

10.1007/s00393-018-0574-7

PubMed ID:

30627844

Uncontrolled Keywords:

Anti-eosinophil therapy Cytoplasmatic granules Eotaxin Extracellular traps Interleukin-5

BORIS DOI:

10.7892/boris.125010

URI:

https://boris.unibe.ch/id/eprint/125010

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