Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping

Wulfkuhle, Julia D; Berg, Daniela; Wolff, Claudia; Langer, Rupert; Tran, Kai; Illi, Julie; Espina, Virginia; Pierobon, Mariaelena; Deng, Jianghong; DeMichele, Angela; Walch, Axel; Bronger, Holger; Becker, Ingrid; Waldhör, Christine; Höfler, Heinz; Esserman, Laura; Liotta, Lance A; Becker, Karl-Friedrich; Petricoin, Emanuel F (2012). Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping. Clinical cancer research, 18(23), pp. 6426-35. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-0452

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Targeting of the HER2 protein in human breast cancer represents a major advance in oncology but relies on measurements of total HER2 protein and not HER2 signaling network activation. We used reverse-phase protein microarrays (RPMA) to measure total and phosphorylated HER2 in the context of HER family signaling to understand correlations between phosphorylated and total levels of HER2 and downstream signaling activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Langer, Rupert

ISSN:

1078-0432

Publisher:

American Association for Cancer Research

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

11 Jul 2018 17:13

Publisher DOI:

10.1158/1078-0432.CCR-12-0452

PubMed ID:

23045247

Web of Science ID:

000312025600006

URI:

https://boris.unibe.ch/id/eprint/12512 (FactScience: 218866)

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