Implications of the local hemodynamic forces on the formation and destabilization of neoatherosclerotic lesions.

Torii, Ryo; Stettler, Rodrigue; Räber, Lorenz; Zhang, Yao-Jun; Karanasos, Antonis; Dijkstra, Jouke; Patel, Kush; Crake, Tom; Hamshere, Steve; Garcia-Garcia, Hector M; Tenekecioglu, Erhan; Ozkor, Muhiddin; Baumbach, Andreas; Windecker, Stephan; Serruys, Patrick W; Regar, Evelyn; Mathur, Anthony; Bourantas, Christos V (2018). Implications of the local hemodynamic forces on the formation and destabilization of neoatherosclerotic lesions. International journal of cardiology, 272, pp. 7-12. Elsevier 10.1016/j.ijcard.2018.06.065

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OBJECTIVE To examine the implications of endothelial shear stress (ESS) distribution in the formation of neoatherosclerotic lesions. METHODS Thirty six patients with neoatherosclerotic lesions on optical coherence tomography (OCT) were included in this study. The OCT data were used to reconstruct coronary anatomy. Blood flow simulation was performed in the models reconstructed from the stent borders which it was assumed that represented the lumen surface at baseline, immediate after stent implantation, and the estimated ESS was associated with the neointima burden, neoatherosclerotic burden and neointima characteristics. In segments with neointima rupture blood flow simulation was also performed in the model representing the lumen surface before rupture and the ESS was estimated at the ruptured site. RESULTS An inverse association was noted between baseline ESS and the incidence and the burden of neoatherosclerotic (β = -0.60, P < 0.001, and β = -4.05, P < 0.001, respectively) and lipid-rich neoatherosclerotic tissue (β = -0.54, P < 0.001, and β = -3.60, P < 0.001, respectively). Segments exposed to low ESS (<1 Pa) were more likely to exhibit macrophages accumulation (28.2% vs 10.9%, P < 0.001), thrombus (11.0% vs 2.6%, P < 0.001) and evidence of neointima discontinuities (8.1% vs 0.9%, P < 0.001) compared to those exposed to normal or high ESS. In segments with neointima rupture the ESS was high at the rupture site compared to the average ESS over the culprit lesion (4.00 ± 3.65 Pa vs 3.14 ± 2.90 Pa, P < 0.001). CONCLUSIONS Local EES is associated with neoatherosclerotic lesion characteristics, which suggests involvement of ESS in the formation of vulnerable plaques in stented segments.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Räber, Lorenz and Windecker, Stephan


600 Technology > 610 Medicine & health








Nadia Biscozzo

Date Deposited:

21 Feb 2019 14:22

Last Modified:

05 Dec 2019 06:29

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Endothelial shear stress Neoatherosclerosis Optical coherence tomography




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