Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2

Regel, Ivonne; Merkl, Lisa; Friedrich, Teresa; Burgermeister, Elke; Zimmermann, Wolfgang; Einwächter, Henrik; Herrmann, Ken; Langer, Rupert; Röcken, Christoph; Hofheinz, Ralf; Schmid, Roland; Ebert, Matthias P (2012). Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2. Gastroenterology, 143(1), 99-109.e10. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2012.03.035

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Chemotherapy modestly prolongs survival of patients with advanced gastric cancer, but strategies are needed to increase its efficacy. Histone deacetylase (HDAC) inhibitors modify chromatin and can block cancer cell proliferation and promote apoptosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Langer, Rupert

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

17 Mar 2015 21:20

Publisher DOI:

10.1053/j.gastro.2012.03.035

PubMed ID:

22465428

Web of Science ID:

000305781500033

URI:

https://boris.unibe.ch/id/eprint/12521 (FactScience: 218875)

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