Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer's Disease.

Laugisch, Oliver; Johnen, Andreas; Maldonado, Alejandra; Ehmke, Benjamin; Bürgin, Walter; Olsen, Ingar; Potempa, Jan; Sculean, Anton; Duning, Thomas; Eick, Sigrun (2018). Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer's Disease. Journal of Alzheimer's disease, 66(1), pp. 105-114. IOS Press 10.3233/JAD-180620

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BACKGROUND

Recent studies suggest a link between periodontitis and Alzheimer's disease (AD).

OBJECTIVE

Verification of the presence of periodontal pathogens and the intrathecal generation of pathogen-specific antibodies in 20 patients with AD and 20 with other forms of dementia (DEM-noAD).

METHODS

Clinical periodontal indices were recorded. Cerebrospinal fluid (CSF) was analyzed for total tau protein (T-tau) and amyloid-β (Aβ1-42). In serum and CSF, antibody levels against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema species were quantified. The presence of selected bacteria and inflammatory biomarkers were determined in periodontium, serum, and CSF.

RESULTS

In line with diagnoses, CSF-levels of Aβ1-42 were significantly lower in AD than DEM-noAD patients. Periodontal destruction and inflammation were omnipresent with no difference between groups. P. gingivalis, T. forsythia, and Treponema species were detected in more than 50% of subgingival biofilm samples, but neither in serum nor in the CSF. Elevated levels of anti-pathogen antibodies in CSF of 16 patients (7 AD; 9 DEM-noAD) compared to serum highlight a possibility of the intrathecal immune response to pathogens. There was no significant difference in antibodies levels against selected bacteria in CSF and serum between groups. Multivariate regression analysis and general linear models revealed an association of the T-tau level in AD group with both serum levels of anti-P. gingivalis antibodies and MCP-1/CCL-2.

CONCLUSION

Periodontal pathogens may enter the brain and stimulate a local immune response. However, in patients with dementia at the age up to 70 years, periodontal pathogens do not act as a trigger for developing AD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Sculean, Anton and Eick, Sigrun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1387-2877

Publisher:

IOS Press

Language:

English

Submitter:

Doris Burri

Date Deposited:

17 Apr 2019 14:12

Last Modified:

17 Apr 2019 14:12

Publisher DOI:

10.3233/JAD-180620

PubMed ID:

30223397

Uncontrolled Keywords:

Alzheimer’s disease Porphyromonas gingivalis dementia periodontal pathogens periodontitis

URI:

https://boris.unibe.ch/id/eprint/125223

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