The use of platelet-rich plasma to enhance the outcomes of implant therapy: A systematic review.

Stähli, Alexandra Beatrice; Strauss, Franz Josef; Gruber, Reinhard (2018). The use of platelet-rich plasma to enhance the outcomes of implant therapy: A systematic review. Clinical oral implants research, 29(Suppl. 18), pp. 20-36. Wiley-Blackwell 10.1111/clr.13296

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OBJECTIVE To assess the effect of platelet-rich plasma (PRP) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRP administration for bone regeneration and implant therapy? METHODS A literature search was conducted involving three databases: MEDLINE, EMBASE and Cochrane database followed by a hand search of relevant scientific journals. Human studies using PRP for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included. Eligible studies were selected based on the inclusion criteria, and quality assessments were conducted. RESULTS In total, out from the 9,497 titles meeting the original search criteria, 22 fulfilled the inclusion criteria and were chosen for data extraction. Among them were 15 randomized controlled trials (RCT) and seven controlled clinical trials (CCT). Overall, the risk of bias was moderate to high. A total of seven studies showed superior outcomes when PRP was added during sinus floor elevation and five showed no superior outcome. Three studies found a significant advantage of PRP for alveolar bone regeneration and another three studies for soft tissue healing. Three studies reported on beneficial effects of PRP directly during implant placement while another study failed to find significant differences. Due to the heterogeneity of study designs, no meta-analysis could be performed. SUMMARY AND CONCLUSIONS Despite the lack of consistent evidence supporting the clinical benefit of PRP in healthy patients, PRP might have a positive effect on wound healing and bone regeneration in compromised patients.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Stähli, Alexandra Beatrice and Gruber, Reinhard


600 Technology > 610 Medicine & health








Doris Burri

Date Deposited:

26 Jun 2019 09:28

Last Modified:

24 Oct 2019 04:06

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

alveolar ridge preservation bone regeneration implant therapy platelet-rich plasma sinus floor elevation




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