Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort.

Alaraudanjoki, Viivi Karoliina; Koivisto, Salla; Pesonen, Paula; Männikkö, Minna; Leinonen, Jukka; Tjäderhane, Leo; Laitala, Marja-Liisa; Lussi, Adrian; Anttonen, Vuokko Anna-Marketta (2019). Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort. Caries research, 53(1), pp. 49-59. Karger 10.1159/000488208

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Erosive tooth wear is defined as irreversible loss of dental tissues due to intrinsic or extrinsic acids, exacerbated by mechanical forces. Recent studies have suggested a higher prevalence of erosive tooth wear in males, as well as a genetic contribution to susceptibility to erosive tooth wear. Our aim was to examine erosive tooth wear by performing a genome-wide association study (GWAS) in a sample of the Northern Finland Birth Cohort 1966 (n = 1,962). Erosive tooth wear was assessed clinically using the basic erosive wear examination. A GWAS was performed for the whole sample as well as separately for males and females. We identified one genome-wide significant signal (rs11681214) in the GWAS of the whole sample near the genes PXDN and MYT1L. When the sample was stratified by sex, the strongest genome-wide significant signals were observed in or near the genes FGFR1, C8orf86, CDH4, SCD5, F2R, and ING1. Additionally, multiple suggestive association signals were detected in all GWASs performed. Many of the signals were in or near the genes putatively related to oral environment or tooth development, and some were near the regions considered to be associated with dental caries, such as 2p24, 4q21, and 13q33. Replications of these associations in other samples, as well as experimental studies to determine the biological functions of associated genetic variants, are needed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Lussi, Adrian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0008-6568

Publisher:

Karger

Language:

English

Submitter:

Hendrik Meyer-Lückel

Date Deposited:

15 Apr 2019 18:26

Last Modified:

15 Apr 2019 18:26

Publisher DOI:

10.1159/000488208

PubMed ID:

29898447

Uncontrolled Keywords:

Adult Dental erosion Epidemiology Gender Genome Genome-wide association study

BORIS DOI:

10.7892/boris.125273

URI:

https://boris.unibe.ch/id/eprint/125273

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