Losartan reverses impaired osseointegration in spontaneously hypertensive rats.

Mulinari-Santos, Gabriel; de Souza Batista, Fábio Roberto; Kirchweger, Franziska; Tangl, Stefan; Gruber, Reinhard; Okamoto, Roberta (2018). Losartan reverses impaired osseointegration in spontaneously hypertensive rats. Clinical oral implants research, 29(11), pp. 1126-1134. Wiley-Blackwell 10.1111/clr.13376

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OBJECTIVE Hypertension is not only associated with cardiovascular diseases but also with alterations in bone quality. Hypertension therefore might be a risk factor for osseointegration. Preclinical studies suggest that losartan, an angiotensin II receptor blocker widely used to treat hypertension, has a beneficial effect in graft consolidation. Here, we determine the effect of hypertension and losartan on osseointegration. METHODS We used spontaneously hypertensive rats (SHR) and normotensive Wistar albinus rats receiving losartan (30 mg/kg, p.o.) or left untreated. After 1 week, titanium miniscrews were inserted into the tibia. Sixty days after implantation, implant stability was evaluated by removal torque measurement considered the primary endpoint. Microcomputed tomography and histomorphometric analysis were secondary endpoints. RESULTS Losartan increased the removal torque in the hypertensive SHR group to levels of the Wistar controls. While the cortical parameters of osseointegration remained unchanged, losartan increased medullary bone formation. Microcomputed tomography revealed a higher bone volume per tissue volume and trabecular thickness in the SHR rats treated with losartan. Histomorphometric analysis further showed that losartan significantly increased the thickness of newly formed bone in medullary area in hypertensive SHR rats. Losartan did not significantly alter the parameters of osseointegration in normotensive rats. CONCLUSIONS The data presented suggest that the angiotensin II receptor antagonist losartan increases the medullary parameters of osseointegration in a tibia model of spontaneously hypertensive rats. Considering the study limitations, understanding the impact of hypertension and the respective drugs on osseointegration requires further research.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Gruber, Reinhard


600 Technology > 610 Medicine & health








Doris Burri

Date Deposited:

26 Jun 2019 09:47

Last Modified:

24 Oct 2019 12:14

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

bone losartan osseointegration renin-angiotensin system spontaneously hypertensive rats





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