Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties.

Bierbaumer, Lisa; Schwarze, Uwe Yacine; Gruber, Reinhard; Neuhaus, Winfried (2018). Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties. Tissue barriers, 6(3), p. 1479568. Taylor & Francis 10.1080/21688370.2018.1479568

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Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a transport and a metabolic barrier, and all these barrier components play pivotal roles in the communication between saliva and blood. The sum of all epithelia of the oral cavity and salivary glands is defined as the blood-saliva barrier. The functionality of the barrier is regulated by its microenvironment and often altered during diseases. A huge array of cell culture models have been developed to mimic specific parts of the blood-saliva barrier, but no ultimate standard in vitro models have been established. This review provides a comprehensive overview about developed in vitro models of oral mucosal barriers, their applications, various cultivation protocols and corresponding barrier properties.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Gruber, Reinhard

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2168-8370

Publisher:

Taylor & Francis

Language:

English

Submitter:

Doris Burri

Date Deposited:

18 Jul 2019 13:52

Last Modified:

22 Oct 2019 20:58

Publisher DOI:

10.1080/21688370.2018.1479568

PubMed ID:

30252599

Uncontrolled Keywords:

ABC-transporters SLC-transporter craniomaxillofacial surgery desmosomes gingivitis periodontitis saliva salivary gland tight junctions tongue

BORIS DOI:

10.7892/boris.125317

URI:

https://boris.unibe.ch/id/eprint/125317

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