Telomere length and genetic variations affecting telomere length as biomarkers for facial regeneration with platelet-rich fibrin based on the low-speed centrifugation concept.

Nacopoulos, Cleopatra; Gkouskou, Kalliopi; Karypidis, Dimitrios; Vlastos, Ioannis; Vesala, Anna-Maria; Choukroun, Joseph; Miron, Richard John; Prokopakis, Emmanuel (2019). Telomere length and genetic variations affecting telomere length as biomarkers for facial regeneration with platelet-rich fibrin based on the low-speed centrifugation concept. Journal of cosmetic dermatology, 18(1), pp. 408-413. Blackwell Science 10.1111/jocd.12666

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BACKGROUND Platelet-Rich Fibrin (PRF), a fibrin matrix produced by single blood centrifugation that contains leukocytes, platelets, and growth factors, is increasingly being utilized for facial regeneration purposes. However, our understanding of the involved pathophysiological mechanisms affecting regeneration is limited and current protocols require better optimization. Biomarkers that are related to skin aging such as telomere length (TL) have been proposed as a mean to analyze patients' stratification. OBJECTIVE Our aim is to study whether the outcomes of a facial regeneration protocol performed with PRF are related to TL and genetic variations affecting TL. This can aid in the standardization of a surgical aesthetic protocol. PATIENTS AND METHODS In all, 41 patients treated with PRF produced with the low-speed centrifugation concept were included in this observational study. The correlation between TL and genetic variations were assessed versus treatment outcomes, namely the number of sessions and aesthetic results utilizing the FACE-Q skin satisfaction questionnaire. RESULTS In all, 39 of the 41 patients completed the treatment. TL correlated with the initial responses to FACE-Q (ρ = .33, P = .05). Genetic variations affecting TL was related to the change of FACE-Q (ρ = .35, P = .034) as well as to the number of treatment sessions (ρ = .38, P = .019). CONCLUSIONS Telomere length (TL) was related to patient perceived facial skin appearance. In addition, genetic variations affecting TL were related to the final outcomes (number of sessions and improvements of FACE-Q results) and may be a useful biomarker for future regenerative procedures performed with PRF for facial regeneration.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Miron, Richard John

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1473-2130

Publisher:

Blackwell Science

Language:

English

Submitter:

Doris Burri

Date Deposited:

16 Apr 2019 14:18

Last Modified:

24 Oct 2019 18:59

Publisher DOI:

10.1111/jocd.12666

PubMed ID:

29761887

Uncontrolled Keywords:

biomarkers facial regeneration platelet-rich fibrin telomere length

BORIS DOI:

10.7892/boris.125320

URI:

https://boris.unibe.ch/id/eprint/125320

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