Influence of autogenous platelet concentrate on combined GTR/graft therapy in intra-bony defects: A 13-year follow-up of a randomized controlled clinical split-mouth study.

Cieplik, Fabian; Tabenski, Laura; Hiller, Karl-Anton; Schmalz, Gottfried Hans; Buchalla, Wolfgang; Christgau, Michael (2018). Influence of autogenous platelet concentrate on combined GTR/graft therapy in intra-bony defects: A 13-year follow-up of a randomized controlled clinical split-mouth study. Journal of clinical periodontology, 45(3), pp. 382-391. Wiley 10.1111/jcpe.12855

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AIM To investigate the clinical long-term outcomes 13 years following guided tissue regeneration (GTR) in deep intra-bony defects with and without additional application of autogenous platelet concentrate (APC). METHODS In 25 patients, two deep contra-lateral intra-bony defects were treated according to GTR using β-TCP and bio-resorbable membranes. In test defects, APC was applied additionally. After 13 years, clinical healing results were assessed and compared to results at baseline and after 1 year. Furthermore, a tooth survival analysis was carried out. RESULTS After 13 years, 22 patients were available for tooth survival analysis showing 81.8% of test and 86.4% of control teeth still in situ. Based on the 15 patients still available for split-mouth analysis, median CAL was 10.0 mm in test and 12.0 mm in control sites at baseline. After 1 year, both groups revealed significant CAL gains of 5.0 mm, followed by a new CAL loss of 1.0 mm in the following 12 years. There were no significant differences between test and control sites. CONCLUSION Within the limits of this study, the data show that most of the CAL gain following GTR can be maintained over 13 years. The additional use of APC had no positive influence on the long-term stability.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Schmalz, Gottfried Hans

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0303-6979

Publisher:

Wiley

Language:

English

Submitter:

Doris Burri

Date Deposited:

26 Jun 2019 12:00

Last Modified:

24 Oct 2019 00:00

Publisher DOI:

10.1111/jcpe.12855

PubMed ID:

29247452

Uncontrolled Keywords:

autogenous platelet concentrate guided tissue regeneration intra-bony defects long-term results platelet-rich plasma

BORIS DOI:

10.7892/boris.125323

URI:

https://boris.unibe.ch/id/eprint/125323

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