Clinical periodontal variables in patients with and without dementia - a systematic review and meta-analysis.

Maldonado, Alejandra; Laugisch, Oliver; Bürgin-Mumenthaler, Walter Bruno; Sculean, Anton; Eick, Sigrun (2018). Clinical periodontal variables in patients with and without dementia - a systematic review and meta-analysis. Clinical oral investigations, 22(7), pp. 2463-2474. Springer-Verlag 10.1007/s00784-018-2523-x

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BACKGROUND Considering the increasing number of elderly people, dementia has gained an important role in today's society. Although the contributing factors for dementia have not been fully understood, chronic periodontitis (CP) seems to have a possible link to dementia. AIM To conduct a systematic review including meta-analysis in order to assess potential differences in clinical periodontal variables between patients with dementia and non-demented individuals. METHODS The following focused question was evaluated: is periodontitis associated with dementia? Electronic searches in two databases, MEDLINE and EMBASE, were conducted. Meta-analysis was performed with the collected data in order to find a statistically significant difference in clinical periodontal variables between the group of dementia and the cognitive normal controls. RESULTS Forty-two articles remained for full text reading. Finally, seven articles met the inclusion criteria and only five studies provided data suitable for meta-analysis. Periodontal probing depth (PPD), bleeding on probing (BOP), gingival bleeding index (GBI), clinical attachment level (CAL), and plaque index (PI) were included as periodontal variables in the meta-analysis. Each variable revealed a statistically significant difference between the groups. In an attempt to reveal an overall difference between the periodontal variables in dementia patients and non-demented individuals, the chosen variables were transformed into units that resulted in a statistically significant overall difference (p < 0.00001). CONCLUSION The current findings indicate that compared to systemically healthy individuals, demented patients show significantly worse clinical periodontal variables. However, further epidemiological studies including a high numbers of participants, the use of exact definitions both for dementia and chronic periodontitis and adjusted for cofounders is warranted. CLINICAL RELEVANCE These findings appear to support the putative link between CP and dementia. Consequently, the need for periodontal screening and treatment of elderly demented people should be emphasized.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research

UniBE Contributor:

Maldonado, Alejandra; Laugisch, Oliver; Bürgin-Mumenthaler, Walter Bruno; Sculean, Anton and Eick, Sigrun

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-6981

Publisher:

Springer-Verlag

Language:

English

Submitter:

Doris Burri

Date Deposited:

03 Jul 2019 16:20

Last Modified:

08 Jul 2019 14:05

Publisher DOI:

10.1007/s00784-018-2523-x

PubMed ID:

29934798

Uncontrolled Keywords:

Alzheimer’s disease Clinical periodontal variables Dementia Periodontitis

BORIS DOI:

10.7892/boris.125374

URI:

https://boris.unibe.ch/id/eprint/125374

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