The Effect of Nonsurgical Periodontal Therapy on the Level of Human Neutrophil Peptides 1-3 in Patients with Aggressive Periodontitis.

Dolińska, Ewa; Skurska, Anna; Dymicka-Piekarska, Violetta; Milewski, Robert; Pietruski, Jan; Pietruska, Małgorzata; Sculean, Anton (2017). The Effect of Nonsurgical Periodontal Therapy on the Level of Human Neutrophil Peptides 1-3 in Patients with Aggressive Periodontitis. Oral health & preventive dentistry, 15(6), pp. 557-561. Quintessenz Verlags-GmbH 10.3290/j.ohpd.a38995

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PURPOSE To assess the presence of HNP1-3 in the gingival crevicular fluid (GCF) of patients suffering from aggressive periodontitis before and after nonsurgical periodontal therapy. MATERIALS AND METHODS Twenty patients, each with generalised aggressive periodontitis (GAP) were included in the study. After periodontal examination, one site with a probing depth (PD) ≥ 4 mm was selected. Patients received nonsurgical treatment (scaling and root planing [SRP]) with additional administration of systemic antibiotic therapy (amoxicillin 375 mg three times daily + metronidazole 250 mg three times daily for 7 days). Prior to therapy and 3 and 6 months after, the following parameters were evaluated from the same site: PD, gingival recession (GR), clinical attachment level (CAL), plaque index (PI), bleeding on probing (BOP), sulcus fluid flow rate (SFFR). The level of HNP1-3 in GCF was determined by means of a commercially available ELISA kit. RESULTS Compared to baseline, the level of HNP 1-3 did not show statistically significant differences at 3 and 6 months. The evaluated clinical parameters and SFFR showed statistically significant decreases compared to baseline. At 6 months, PD (median) decreased from 7 to 3.5 and CAL (median) decreased from 7 to 4. CONCLUSION In patients with GAP, nonsurgical periodontal therapy in conjunction with systemic administration of amoxicillin and metronidazole had no effect on the level of HNP1-3 in GCF.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Sculean, Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1602-1622

Publisher:

Quintessenz Verlags-GmbH

Language:

English

Submitter:

Doris Burri

Date Deposited:

30 Jul 2019 14:59

Last Modified:

10 Dec 2019 10:53

Publisher DOI:

10.3290/j.ohpd.a38995

PubMed ID:

28944351

BORIS DOI:

10.7892/boris.125393

URI:

https://boris.unibe.ch/id/eprint/125393

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