Prostate Power Play: Does Accelerate -Deficient Cancer Progression?

Triscott, Joanna; Rubin, Mark A. (2018). Prostate Power Play: Does Accelerate -Deficient Cancer Progression? Cancer discovery, 8(6), pp. 682-685. American Association for Cancer Research 10.1158/2159-8290.CD-18-0369

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PI3K pathway alterations are frequently recurrent in metastatic prostate cancer and are associated with the development of currently incurable castration-resistant disease. Candidate inhibitors that target single PI3K pathway members lack efficacy as demonstrated in multiple clinical trials. In this issue, Pearson and colleagues examine the functional importance of co-occurring and aberrations using a novel mouse model and demonstrate a synergistic acceleration of tumorigenesis that may be responsible for metastatic prostate cancer. .

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Triscott, Joanna Catherine Caprio and Rubin, Mark Andrew

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2159-8290

Publisher:

American Association for Cancer Research

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

17 Dec 2019 13:06

Last Modified:

17 Dec 2019 13:14

Publisher DOI:

10.1158/2159-8290.CD-18-0369

PubMed ID:

29858226

BORIS DOI:

10.7892/boris.125522

URI:

https://boris.unibe.ch/id/eprint/125522

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