Dysfunctional approach behavior triggered by alcohol-unrelated Pavlovian cues predicts long-term relapse in alcohol dependence.

Sommer, Christian; Birkenstock, Julian; Garbusow, Maria; Obst, Elisabeth; Schad, Daniel J; Bernhardt, Nadine; Huys, Quentin M; Wurst, Friedrich M; Weinmann, Wolfgang; Heinz, Andreas; Smolka, Michael N; Zimmermann, Ulrich S (2020). Dysfunctional approach behavior triggered by alcohol-unrelated Pavlovian cues predicts long-term relapse in alcohol dependence. Addiction biology, 25(1), e12703. Wiley-Blackwell 10.1111/adb.12703

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We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a monetary gain. Under that condition, relapsers approached the instrumental stimulus, independent of the expected punishment. The failure of inhibiting an aversive stimulus in favor of approaching an appetitive context cue reflects dysfunctional altered learning mechanisms in relapsers.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine

UniBE Contributor:

Weinmann, Wolfgang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1355-6215

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Antoinette Angehrn

Date Deposited:

13 Mar 2019 10:39

Last Modified:

13 Dec 2019 01:30

Publisher DOI:

10.1111/adb.12703

PubMed ID:

30561790

Uncontrolled Keywords:

alcohol dependence human Pavlovian-to-instrumental transfer relapse

BORIS DOI:

10.7892/boris.125559

URI:

https://boris.unibe.ch/id/eprint/125559

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