Impaired repletion of intramyocellular lipids in patients with growth hormone deficiency after a bout of aerobic exercise.

Loher, Hannah; Jenni, Stefan; Bucher, Julie; Krüsi, Marion; Kreis, Roland; Boesch, Christoph Hans; Christ, Emanuel (2018). Impaired repletion of intramyocellular lipids in patients with growth hormone deficiency after a bout of aerobic exercise. Growth hormone & IGF research, 42-43, pp. 32-39. Elsevier 10.1016/j.ghir.2018.08.001

[img] Text
CMI-3-173.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (313kB) | Request a copy


Ectopic lipids such as intramyocellular lipids (IMCL) are depleted by exercise and repleted by diet, whereas intrahepatocellular lipids (IHCL) are increased immediately after exercise. So far, it is unclear how ectopic lipids behave 24 h after exercise and whether the lack of growth hormone (GH) significantly affects ectopic lipids 24 h after exercise.


Seven male patients with growth hormone deficiency (GHD) and seven sedentary male control subjects (CS) were included. VO was assessed by spiroergometry; visceral and subcutaneous fat by whole body MRI. H-MR-spectroscopy was performed in M. vastus intermedius and in the liver before and after 2 h of exercise at 50% VO and 24 h thereafter, while diet and physical activity were standardized.


Sedentary male subjects (7 GHD, 7 CS) were recruited. Age, BMI, waist circumference, visceral and subcutaneous fat mass was not significantly different between GHD and CS. VO was significantly lower in GHD vs. CS. IMCL were diminished through aerobic exercise in both groups: (-11.5 ± 21.9% in CS; -8.9% ±19.1% in GHD) and restored after 24 h in CS (-5.5 ± 26.6% compared to baseline) but not in GHD (-17.9 ± 15.3%). IHCL increased immediately after exercise and decreased to baseline within 24 h.


These findings suggest that GHD may affect repletion of IMCL 24 h after aerobic exercise.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM

UniBE Contributor:

Jenni, Stefan; Kreis, Roland; Boesch, Christoph Hans and Christ, Emanuel


600 Technology > 610 Medicine & health








Isabelle Ursula Saurer

Date Deposited:

07 Mar 2019 16:25

Last Modified:

05 Dec 2022 15:25

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Ectopic fat Exercise Growth hormone deficiency Intrahepatocellular lipids Intramyocellular lipids




Actions (login required)

Edit item Edit item
Provide Feedback