The assessment of correlation and prognosis among <sup>18</sup>F-FDG uptake parameters, Glut1, pStat1 and pStat3 in surgically resected non-small cell lung cancer patients

Kaida, Hayato; Azuma, Koichi; Kawahara, Akihiko; Sadashima, Eiji; Hattori, Satoshi; Takamori, Shinzo; Akiba, Jun; Fujimoto, Kiminori; Rominger, Axel; Murakami, Takamichi; Ishii, Kazunari; Ishibashi, Masatoshi (2018). The assessment of correlation and prognosis among <sup>18</sup>F-FDG uptake parameters, Glut1, pStat1 and pStat3 in surgically resected non-small cell lung cancer patients. OncoTarget, 9(62), pp. 31971-31984. Impact Journals LLC 10.18632/oncotarget.25865

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Introduction: To assess the correlation among 18F-FDG uptake, Glut1, pStat1 and pStat3, and to investigate the relationship between the prognosis and 18F-FDG uptake and these molecular markers in surgically resected non-small cell lung cancer (NSCLC) patients. Results: Knockdown of Glut1 led to a significant increase in pStat1 expression. Glut1 expression positively correlated with the SUVmax, SUVmean, and TLG significantly (P<0.001). pStat3 expression negatively correlated with all PET parameters significantly (P<0.001). pStat1 had positive weak correlations with the SUVmax and SUVmean. All PET parameters and Glut1 were significantly associated with DFS (P<0.05). TLG, MTV, Glut1 and pStat1 were significantly associated with OS (P<0.05). Conclusion: pStat3 and Glut1 may be associated with 18F-FDG uptake mechanism. TLG, MTV, and Glut1 may be independent prognostic factors. Methods: The SUVmax, SUVmean, MTV and TLG of primary lesions were calculated in 140 patients. The expressions of Glut1 and Stat pathway proteins in NSCLC cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry. OS and DFS were evaluated by the Kaplan-Meier method. The difference in survival between subgroups was analyzed by log-rank test. The prognostic significance of clinicopathological, molecular and PET parameters was assessed by Cox proportional hazard regression analysis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1949-2553

Publisher:

Impact Journals LLC

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

01 Feb 2019 16:23

Last Modified:

10 Nov 2019 06:05

Publisher DOI:

10.18632/oncotarget.25865

PubMed ID:

30174790

Uncontrolled Keywords:

Glut1; non-small cell lung cancer; pStat1; pStat3; volumetric parameters

BORIS DOI:

10.7892/boris.125649

URI:

https://boris.unibe.ch/id/eprint/125649

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