In vivo precision assessment of a near-infrared spectroscopy-based tissue oximeter (OxyPrem v1.3) in neonates considering systemic hemodynamic fluctuations.

Kleiser, Stefan; Ostojic, Daniel; Nasseri, Nassim; Isler, Helene; Bucher, Hans Ulrich; Bassler, Dirk; Wolf, Martin; Scholkmann, Felix; Karen, Tanja (2018). In vivo precision assessment of a near-infrared spectroscopy-based tissue oximeter (OxyPrem v1.3) in neonates considering systemic hemodynamic fluctuations. Journal of biomedical optics, 23(6), pp. 1-10. SPIE International Society for Optical Engineering 10.1117/1.JBO.23.6.067003

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The aim was to determine the precision of a noninvasive near-infrared spectroscopy (NIRS)-based tissue oximeter (OxyPrem v1.3). Using a linear mixed-effects model, we quantified the variability for cerebral tissue oxygenation (StO2) measurements in 35 preterm neonates to be 2.64%, a value that meets the often-articulated clinicians' demand for a precise tissue oxygenation measurement. We showed that the variability of StO2 values measured was dominated by spontaneous systemic hemodynamic fluctuations during the measurement, meaning that precision of the instrument was actually even better. Based on simultaneous and continuous measurements of peripheral arterial oxygenation and cerebral StO2 with a second sensor, we were able to determine and quantify the physiological instability precisely. We presented different methods and analyses aiming at reducing this systematic physiological error of in vivo precision assessments. Using these methods, we estimated the precision of the OxyPrem tissue oximeter to be   ≤  1.85  %  . With our study, we deliver relevant information to establish highly precise cerebral oxygenation measurements with NIRS-based oximetry, facilitating the further development toward a substantially improved diagnosis and treatment of patients with respect to brain oxygenation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

UniBE Contributor:

Nasseri, Nassim and Scholkmann, Felix

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1083-3668

Publisher:

SPIE International Society for Optical Engineering

Language:

English

Submitter:

Yasmine Bühlmann

Date Deposited:

02 Sep 2019 06:59

Last Modified:

26 Oct 2019 15:00

Publisher DOI:

10.1117/1.JBO.23.6.067003

PubMed ID:

29905038

Uncontrolled Keywords:

cerebral oximetry near-infrared spectroscopy precision preterm infant

BORIS DOI:

10.7892/boris.125663

URI:

https://boris.unibe.ch/id/eprint/125663

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