Allergen immunotherapy in people, dogs, cats and horses - differences, similarities and research needs.

Mueller, R S; Jensen-Jarolim, E; Roth-Walter, F; Marti, Eliane Isabelle; Janda, J; Seida, A A; DeBoer, D (2018). Allergen immunotherapy in people, dogs, cats and horses - differences, similarities and research needs. Allergy, 73(10), pp. 1989-1999. Wiley 10.1111/all.13464

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In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis. Initiating a regulatory response and a production of "blocking" IgG antibodies with AIT are similar mechanisms in human beings and dogs with allergic diseases. Although subcutaneous immunotherapy is used for atopic dermatitis in cats, data for its efficacy are sparse. There is some evidence for successful treatment of feline asthma with AIT. In horses, most studies evaluate the effect of AIT on insect hypersensitivity with conflicting results although promising pilot studies have demonstrated the prophylaxis of insect hypersensitivity with recombinant antigens of biting midges (Culicoides spp.). Optimizing AIT using allergoids, peptide immunotherapy, recombinant allergens and new adjuvants with the different administration types of allergen extracts will further improve compliance and efficacy of this proven treatment modality.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Marti, Eliane Isabelle

Subjects:

600 Technology > 630 Agriculture

ISSN:

1398-9995

Publisher:

Wiley

Language:

English

Submitter:

Eliane Isabelle Marti Schalch

Date Deposited:

14 May 2019 11:28

Last Modified:

24 Oct 2019 09:10

Publisher DOI:

10.1111/all.13464

PubMed ID:

29675865

Uncontrolled Keywords:

and tolerance induction animal models asthma atopic dermatitis clinical immunology

BORIS DOI:

10.7892/boris.125684

URI:

https://boris.unibe.ch/id/eprint/125684

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