Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System.

Mohsen, Mona Omar Mahmoud; Gomes, Ariane C; Vogel, Monique; Bachmann, Martin (2018). Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System. Vaccines, 6(3) MDPI 10.3390/vaccines6030037

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Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Mohsen, Mona Omar Mahmoud; Vogel, Monique and Bachmann, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2076-393X

Publisher:

MDPI

Language:

English

Submitter:

Valery Beer

Date Deposited:

01 Apr 2019 13:00

Last Modified:

13 Jun 2019 09:00

Publisher DOI:

10.3390/vaccines6030037

PubMed ID:

30004398

Uncontrolled Keywords:

Toll-like receptor (TLR) adaptive immune system innate immune system virus-like particle (VLP)

BORIS DOI:

10.7892/boris.125729

URI:

https://boris.unibe.ch/id/eprint/125729

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