MicroRNAs as modulators of T cell functions in cancer.

Emming, Stefan; Chirichella, Michele; Monticelli, Silvia (2018). MicroRNAs as modulators of T cell functions in cancer. Cancer letters, 430, pp. 172-178. Elsevier 10.1016/j.canlet.2018.05.019

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MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression post-transcriptionally. They have emerged as important modulators of T lymphocyte biology, influencing cell activation, differentiation and proliferation in response to environmental signals. Here, we will discuss how miRNAs expressed by T cells can influence two key aspects of tumorigenesis, namely the direct, cell-intrinsic oncogenic transformation of T lymphocytes, as well as the indirect effects on tumor growth mediated by altered immune surveillance. We will specifically focus on three miRNAs that have been shown to regulate different aspects of T cell biology in both physiological and pathological conditions, namely miR-155, miR-146a and miR-181a. We aim at providing examples of the fundamental importance of miRNA-regulated networks in determining the fate of T lymphocytes during oncogenic transformation and in the control of tumor growth.

Item Type:

Journal Article (Review Article)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0304-3835

Publisher:

Elsevier

Language:

English

Submitter:

Marlene Wolf Tobler

Date Deposited:

07 May 2019 07:57

Last Modified:

22 Oct 2019 23:06

Publisher DOI:

10.1016/j.canlet.2018.05.019

PubMed ID:

29800683

Uncontrolled Keywords:

Cytokines Effector functions Oncogenic transformation T lymphocytes microRNAs oncomiR

BORIS DOI:

10.7892/boris.125758

URI:

https://boris.unibe.ch/id/eprint/125758

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