Leadless cardiac resynchronization therapy - an in-vivo proof-of-concept study of wireless pacemaker synchronization.

Bereuter, Lukas; Niederhauser, Thomas; Kucera, Martin; Loosli, Dominic; Steib, Immanuel; Schildknecht, Marcel; Zurbuchen, Adrian; Noti, Fabian; Tanner, Hildegard; Reichlin, Tobias Roman; Haeberlin, Andreas (2019). Leadless cardiac resynchronization therapy - an in-vivo proof-of-concept study of wireless pacemaker synchronization. Heart rhythm, 16(6), pp. 936-942. Elsevier 10.1016/j.hrthm.2019.01.010

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BACKGROUND Contemporary leadless pacemakers (PMs) only feature single-chamber ventricular pacing. However, the majority of patients requires dual-chamber pacing or cardiac resynchronization therapy (CRT). Several leadless PMs implanted in the same heart would make that possible if they are able to synchronize their activity in an efficient, safe and reliable way. Thus, a dedicated ultra-low-power wireless communication method for pacemaker synchronization is required. OBJECTIVE The purpose of this study was to develop a leadless CRT system and to evaluate its function in vivo. METHODS Device synchronization was implemented using conductive intracardiac communication (CIC). Communication frequencies were optimized for intracardiac device-device communication. Energy consumption, safety, and reliability of the leadless PM system were tested in animal experiments. RESULTS We successfully performed CRT pacing with three independent devices synchronizing their action using CIC. No arrhythmias were induced by the novel communication technique. 98% of all communication impulses were transmitted successfully. The optimal communication frequency was around 1 MHz with a corresponding transmitted power of only 0.3 μW at a heart rate of 60 beats per minute. CONCLUSION Leadless pacemakers are able to synchronize their action using CIC and may overcome the key limitation of contemporary leadless pacemakers.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Reichlin, Tobias Roman


600 Technology > 610 Medicine & health








Tobias Roman Reichlin

Date Deposited:

27 Mar 2019 17:20

Last Modified:

27 Oct 2019 03:56

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

intra-body communication intracardiac communication leadless cardiac resynchronization therapy leadless pacemaker leadless pacing pacemaker





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