The impact of different doses of indocyanine green on the sentinel lymph-node mapping in early stage endometrial cancer.

Papadia, Andrea; Buda, Alessandro; Gasparri, Maria Luisa; Di Martino, Giampaolo; Bussi, Beatrice; Verri, Debora; Mueller, Michael (2018). The impact of different doses of indocyanine green on the sentinel lymph-node mapping in early stage endometrial cancer. Journal of cancer research and clinical oncology, 144(11), pp. 2187-2191. Springer 10.1007/s00432-018-2716-3

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INTRODUCTION Aim of the study is to evaluate the impact of different doses of indocyanine green (ICG) on the sentinel lymph-node (SLN) mapping in endometrial cancer (EC). MATERIALS AND METHODS A retrospective analysis of EC patients undergoing a laparoscopic SLN mapping at two institutions was performed. Two different injection protocols were used (protocol # 1: 5 mg/ml and a volume of 8 ml; protocol # 2: 1.25 mg/ml and a volume of 4 ml). In every case, the injection was intracervical. The laparoscopic equipment adopted was the same among both institutions. Overall and bilateral detection rates (DR) and median number of retrieved SLNs were calculated. At uni- and multivariate analysis factors (including ICG dose) associated with DR and number of detected SLNs were investigated. RESULTS Overall, 168 patients were included. The overall and bilateral DR were 96.3 and 84.5%. Median number of removed SLNs was 3 (0-18). In 56% of the patients, a median number of 6 (1-93) non-SLNs (NSLNs) were removed. Seventeen (10.1%) patients had metastatic SLNs. At multivariate analysis, no factors were associated with bilateral DR. ICG dose was the only factor associated with number of removed SLNs at multivariate analysis. CONCLUSION A larger dose of ICG is associated with a higher number of retrieved SLNs but not with an increased bilateral DR.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie

UniBE Contributor:

Papadia, Andrea and Mueller, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-1335

Publisher:

Springer

Language:

English

Submitter:

Monika Zehr

Date Deposited:

19 Mar 2019 12:42

Last Modified:

24 Oct 2019 05:56

Publisher DOI:

10.1007/s00432-018-2716-3

Related URLs:

PubMed ID:

30043278

Uncontrolled Keywords:

Dose Endometrial cancer Indocyanine green Laparoscopy Sentinel lymph-node mapping

BORIS DOI:

10.7892/boris.125822

URI:

https://boris.unibe.ch/id/eprint/125822

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