MiRNAs and their interplay with PI3K/AKT/mTOR pathway in ovarian cancer cells: a potential role in platinum resistance.

Gasparri, Maria Luisa; Besharat, Zein Mersini; Farooqi, Ammad Ahmad; Khalid, Sumbul; Taghavi, Katayoun; Besharat, Raad Aris; Sabato, Claudia; Papadia, Andrea; Panici, Pierluigi Benedetti; Mueller, Michael; Ferretti, Elisabetta (2018). MiRNAs and their interplay with PI3K/AKT/mTOR pathway in ovarian cancer cells: a potential role in platinum resistance. Journal of cancer research and clinical oncology, 144(12), pp. 2313-2318. Springer 10.1007/s00432-018-2737-y

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Ovarian cancer is a leading cause of death among gynecologic malignancies. This disappointing prognosis is closely related to intrinsic or acquired resistance to conventional platinum-based chemotherapy, which can affect a third of patients. As such, investigating relevant molecular targets is crucial in the fight against this disease. So far, many mutations involved in ovarian cancer pathogenesis have been identified. Among them, a few pathways were implicated. One such pathway is the P13K/AKT/mTOR with abnormalities found in many cases. This pathway is considered to have an instrumental role in proliferation, migration, invasion and, more recently, in chemotherapy resistance. Many miRNAs have been found to influence P13K/AKT/mTOR pathway with different potential role in tumor genesis and ovarian cancer behaviour. In particular, their biological function was recently investigated as regards chemoresistance, therefore, leading to the identification of potential specific indirect biomarker of platinum sensitivity in ovarian cancer.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Papadia, Andrea and Mueller, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-1335

Publisher:

Springer

Language:

English

Submitter:

Monika Zehr

Date Deposited:

19 Mar 2019 12:49

Last Modified:

23 Oct 2019 19:44

Publisher DOI:

10.1007/s00432-018-2737-y

PubMed ID:

30109500

Uncontrolled Keywords:

MicroRNA Ovarian cancer PI3K/AKT/mTOR pathway Platinum resistance

BORIS DOI:

10.7892/boris.125863

URI:

https://boris.unibe.ch/id/eprint/125863

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