Progesterone Resistance in Endometriosis: an Acquired Property?

Mc Kinnon, Brett; Mueller, Michael; Montgomery, Grant (2018). Progesterone Resistance in Endometriosis: an Acquired Property? Trends in endocrinology and metabolism, 29(8), pp. 535-548. Elsevier Current Trends 10.1016/j.tem.2018.05.006

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Endometriosis is the growth of endometrial tissue outside the uterus and is characterized by progesterone resistance and changes in global and progesterone target gene expression. However, the mechanism behind this and whether it is innate, acquired, or present in both the eutopic and ectopic tissue in not always clear. We find large-scale gene expression studies in eutopic tissue, indicative of progesterone resistance, are often contradictory, potentially due to the dynamic nature of this tissue, whereas suppressed progesterone receptor expression is supported in ectopic but not eutopic tissue. This suggests more studies are required in eutopic tissue particularly, and that potentially the suppressed progesterone receptor (PR) expression is a consequence of the pathogenic process and exposure to the peritoneal environment.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie

UniBE Contributor:

Mc Kinnon, Brett and Mueller, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1043-2760

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Monika Zehr

Date Deposited:

03 Apr 2019 15:44

Last Modified:

22 Oct 2019 22:47

Publisher DOI:

10.1016/j.tem.2018.05.006

PubMed ID:

29934050

Uncontrolled Keywords:

ectopic endometrium endometriosis eutopic endometrium gene expression progesterone progesterone receptor

BORIS DOI:

10.7892/boris.125870

URI:

https://boris.unibe.ch/id/eprint/125870

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