Cryptogenic Stroke and Patent Foramen Ovale.

Mojadidi, Mohammad K; Zaman, Muhammad O; Elgendy, Islam Y; Mahmoud, Ahmed N; Patel, Nimesh K; Agarwal, Nayan; Tobis, Jonathan M; Meier, Bernhard (2018). Cryptogenic Stroke and Patent Foramen Ovale. Journal of the American College of Cardiology, 71(9), pp. 1035-1043. Elsevier 10.1016/j.jacc.2017.12.059

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Nearly one-half of patients with cryptogenic stroke have a patent foramen ovale (PFO). The dilemma of whether to close these PFOs percutaneously, in an effort to reduce the risk of recurrent paradoxical embolism, has been a matter of ongoing debate for more than a decade. Early randomized clinical trials failed to demonstrate a significant benefit of percutaneous PFO closure for secondary prevention of cryptogenic stroke in an intention-to-treat analysis. The long-term follow-up data from the RESPECT trial and 2 new randomized trials (CLOSE and REDUCE) have clarified these findings. They showed that with good patient selection, transcatheter PFO closure significantly reduces the risk of recurrent stroke compared with medical therapy in patients with cryptogenic stroke, with no increased risk of serious adverse events or influence on major bleeding.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Meier, Bernhard

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0735-1097

Publisher:

Elsevier

Language:

English

Submitter:

Luana Cauto

Date Deposited:

27 Feb 2019 14:11

Last Modified:

27 Feb 2019 14:11

Publisher DOI:

10.1016/j.jacc.2017.12.059

PubMed ID:

29495983

Uncontrolled Keywords:

anticoagulants patent foramen ovale right-to-left shunt septal occluder transesophageal echocardiography transient ischemic attack

BORIS DOI:

10.7892/boris.126017

URI:

https://boris.unibe.ch/id/eprint/126017

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