[Fertility Preservation in Prepubertal und Pubertal Children and Adolescents].

Sänger, Nicole; Jarisch, Andrea; Ochsendorf, Falk; Klingebiel, Thomas; Liebenthron, Jana; Kliesch, Sabine; von Wolff, Michael (2018). [Fertility Preservation in Prepubertal und Pubertal Children and Adolescents]. (In Press). Klinische Pädiatrie Thieme 10.1055/s-0044-100396

Text 29421840.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (944kB)

BACKGROUND

Due to rising survival rates in cancer and autoimmune diseases fertility preservation before gonadotoxic therapies has become increasingly important. Although fertility can be significantly affected by gonadotoxic therapies, the possibility of fertility preservation during childhood has not been sufficiently considered so far.

METHODS

Selective literature research with presentation of fertility preservation methods, their indications, implementations, risks and efficacy.

RESULTS

Measures are indicated in all girls and boys at high risk of gonadal damage. The complexity of the techniques requires special expertise in the counseling and implementation, which is offered to girls in counselling Germany especially in the centers of FertiPROTEKT (www.fertiprotekt.com). In girls, mainly cryopreservation of ovary tissue is considered. In postpubertal girls cryopreservation of oocytes is also possible. In postpubertal boys sperm can be preserved. Freezing of testicular tissue is still experimental in prepubertal boys. Success rates are still difficult to quantify; birth rates of about 50% are discussed. All procedures are not covered by health insurance.

CONCLUSION

In children and adolescents, measures of fertility preservation should be considered in cases of highly gonadotoxic therapies, and appropriate advice should be given by specialists.

Interest & Impact

Downloads

2 since deposited on 08 Apr 2019
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item