[Fertility Preservation in Prepubertal und Pubertal Children and Adolescents].

Sänger, Nicole; Jarisch, Andrea; Ochsendorf, Falk; Klingebiel, Thomas; Liebenthron, Jana; Kliesch, Sabine; von Wolff, Michael (2018). [Fertility Preservation in Prepubertal und Pubertal Children and Adolescents]. (In Press). Klinische Pädiatrie Thieme 10.1055/s-0044-100396

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BACKGROUND

Due to rising survival rates in cancer and autoimmune diseases fertility preservation before gonadotoxic therapies has become increasingly important. Although fertility can be significantly affected by gonadotoxic therapies, the possibility of fertility preservation during childhood has not been sufficiently considered so far.

METHODS

Selective literature research with presentation of fertility preservation methods, their indications, implementations, risks and efficacy.

RESULTS

Measures are indicated in all girls and boys at high risk of gonadal damage. The complexity of the techniques requires special expertise in the counseling and implementation, which is offered to girls in counselling Germany especially in the centers of FertiPROTEKT (www.fertiprotekt.com). In girls, mainly cryopreservation of ovary tissue is considered. In postpubertal girls cryopreservation of oocytes is also possible. In postpubertal boys sperm can be preserved. Freezing of testicular tissue is still experimental in prepubertal boys. Success rates are still difficult to quantify; birth rates of about 50% are discussed. All procedures are not covered by health insurance.

CONCLUSION

In children and adolescents, measures of fertility preservation should be considered in cases of highly gonadotoxic therapies, and appropriate advice should be given by specialists.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

von Wolff, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-3824

Publisher:

Thieme

Language:

German

Submitter:

Monika Zehr

Date Deposited:

08 Apr 2019 15:55

Last Modified:

05 Dec 2022 15:26

Publisher DOI:

10.1055/s-0044-100396

PubMed ID:

29421840

BORIS DOI:

10.7892/boris.126040

URI:

https://boris.unibe.ch/id/eprint/126040

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