Lymph node evaluation in high-risk early stage endometrial cancer: A multi-institutional retrospective analysis comparing the sentinel lymph node (SLN) algorithm and SLN with selective lymphadenectomy.

Buda, Alessandro; Gasparri, Maria Luisa; Puppo, Andrea; Mereu, Liliana; De Ponti, Elena; Di Martino, Giampaolo; Novelli, Antonia; Tateo, Saverio; Mueller, Michael; Landoni, Fabio; Papadia, Andrea (2018). Lymph node evaluation in high-risk early stage endometrial cancer: A multi-institutional retrospective analysis comparing the sentinel lymph node (SLN) algorithm and SLN with selective lymphadenectomy. Gynecologic oncology, 150(2), pp. 261-266. Elsevier 10.1016/j.ygyno.2018.06.003

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OBJECTIVE The aim of this study was to determine the impact of the sentinel lymph node mapping algorithm (SLN-A) on the staging in high-risk endometrial cancer (EC) compared to SLN plus selective lymphadenectomy (S-LND). METHODS We retrospectively analyzed the database from a multicenter collaboration that included women with high risk features who underwent primary surgical staging. RESULTS One-hundred and seventy-one women were identified (171), 66 in the SLN-A and 105 in the S-LND group, respectively. Pelvic LD was performed on 115 patients (67.2%) and aortic dissection was performed in 54/105 of the women in the S-LND group (51%). The 5-year comparison did not show a significant difference in the strategy adopted for nodal staging, regarding disease-free survival (DFS) [HR: 0.82; 95% CI 0.53-1.28; p = 0.390]. CONCLUSIONS In this study focusing on women with EC in the HR groups, we did not find a difference in the 5-year DFS when comparing the SLN-A strategy with S-LND. The SLN strategy did not seem to compromise the prognosis of patients with a higher risk of recurrence.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Mueller, Michael and Papadia, Andrea

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0090-8258

Publisher:

Elsevier

Language:

English

Submitter:

Monika Zehr

Date Deposited:

11 Feb 2019 14:43

Last Modified:

04 Dec 2019 02:59

Publisher DOI:

10.1016/j.ygyno.2018.06.003

PubMed ID:

29887483

Uncontrolled Keywords:

High-risk endometrial cancer Nodal staging Selective lymphadenectomy Sentinel node mapping

BORIS DOI:

10.7892/boris.126048

URI:

https://boris.unibe.ch/id/eprint/126048

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