Emerging Implications of Genetic Testing in Inherited Primary Arrhythmia Syndromes.

Asatryan, Babken; Medeiros-Domingo, Argelia (2019). Emerging Implications of Genetic Testing in Inherited Primary Arrhythmia Syndromes. Cardiology in review, 27(1), pp. 23-33. Wolters Kluwer 10.1097/CRD.0000000000000203

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Inherited primary arrhythmia syndromes are genetically determined disorders of cardiac ion channels or ion channel macromolecular complexes usually associated with a higher risk of sudden cardiac death. These conditions have a very broad spectrum of clinical manifestations, ranging from an asymptomatic course to syncope, atrial and ventricular arrhythmias, and conduction disturbances, but may produce sudden infant death syndrome and unexplained sudden cardiac death in apparently healthy individuals. During the last 20 years, the evolving knowledge on the genetic basis of inherited arrhythmia syndromes has dramatically reshaped our understanding of these conditions and, consequently, had a great impact on patient care. Based on the knowledge of the genetic substrates, specific risk factors for individual genotypes have been identified, and various investigations have been launched with the intention of developing a gene- and even mutation-specific therapy. Preliminary results from animal studies suggest that gene therapy rescues the normal ion channel function and thereby prevents cardiac events in some primary arrhythmia syndromes, which suggests that upon appropriate validation in a clinical setting, it may become available for affected patients. The purpose of this review is to provide clinicians with a contemporary insight into the role of genetic testing in the diagnosis, therapy, and prognosis of patients with primary arrhythmia syndromes, and the clinical implications of screening family members who are at risk of sudden cardiac death.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Asatryan, Babken

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1538-4683

Publisher:

Wolters Kluwer

Language:

English

Submitter:

Babken Asatryan

Date Deposited:

08 Mar 2019 15:44

Last Modified:

08 Mar 2019 15:48

Publisher DOI:

10.1097/CRD.0000000000000203

PubMed ID:

29528859

BORIS DOI:

10.7892/boris.126061

URI:

https://boris.unibe.ch/id/eprint/126061

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