Medication-related dental implant failure: Systematic review and meta-analysis.

Chappuis, Vivianne; Avila-Ortiz, Gustavo; Araújo, Mauricio G; Monje, Alberto (2018). Medication-related dental implant failure: Systematic review and meta-analysis. Clinical oral implants research, 29(S16), pp. 55-68. Wiley-Blackwell 10.1111/clr.13137

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OBJECTIVES

The aim of this systematic review was to investigate the association between the intake of systemic medications that may affect bone metabolism and their subsequent impact on implant failures.

MATERIAL AND METHODS

Electronic and manual literature searches were conducted. Implant failure (IF) was the primary outcome, while biological/mechanical and the causes/timing associated with IF were set as secondary outcomes. Meta-analyses for the binary outcome IF and odds ratio were performed to investigate the association with medications.

RESULTS

A final selection of 17 articles was screened for qualitative assessment. As such, five studies focused on evaluating the association of implant failure and non-steroidal anti-inflammatory drugs (NSAIDs), two on selective serotonin reuptake inhibitors (SSRIs), two on proton pump inhibitors (PPIs), seven on bisphosphonates (BPs), and one on anti-hypertensives (AHTNs). For PPIs, the fixed effect model estimated a difference of IF rates of 4.3%, indicating significantly higher IF rates in the test compared to the control group (p < 0.5). Likewise, for SSRIs, the IF was shown to be significantly higher in the individuals taking SSRIs (p < 0.5) as estimated a difference of 7.5%. No subset meta-analysis could be conducted for AHTNs medications as only one study fulfilled the inclusion criteria, which revealed an increased survival rate of AHTN medication. None of the other medications yielded significance.

CONCLUSIONS

The present systematic review showed an association of PPIs and SSRIs with an increased implant failure rate. Hence, clinicians considering implant therapy should be aware of possible medication-related implant failures.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Research
04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology

UniBE Contributor:

Chappuis, Vivianne and Monje, Alberto

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0905-7161

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Caroline Balz

Date Deposited:

27 Mar 2019 12:01

Last Modified:

24 Oct 2019 07:33

Publisher DOI:

10.1111/clr.13137

PubMed ID:

30328197

Uncontrolled Keywords:

biological complications dental implant drug endosseous implant epidemiology failure medication

BORIS DOI:

10.7892/boris.126092

URI:

https://boris.unibe.ch/id/eprint/126092

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