Beyer, L.; Schnabel, J.; Kazmierczak, P.; Schönecker, S.; Prix, C.; Meyer-Wilmes, J.; Unterrainer, M.; Catak, C.; Pogarell, O.; Perneczky, R.; Ewers, M.; Bartenstein, P.; Danek, A.; Bürger, K.; Levin, J.; Rominger, Axel Oliver; Brendel, M. (2018). Neuronal Injury Biomarkers for Assessment of Cognitive Reserve in Alzheimer’s Disease. European journal of nuclear medicine and molecular imaging, 45(S1), S228-S229. Springer-Verlag
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Introduction: The model of cognitive reserve has been extensively
investigated in patients with Alzheimer’s Disease (AD).
Many factors could be identified as being influencing or predictive
for a higher cognitive reserve. Neuronal injury correlates
with cognitive decline in AD with [18F]-fluordesoxyglucose
positron-emission-tomography (FDG-PET), structural MRI and
total tau in cerebrospinal fluid (CSFt-tau) as the most important
biomarkers of neuronal injury according to the A/T/N-classification.
The aim of this study was to compare neuronal injury
biomarkers with the cognitive performance and further cognitive
development to evaluate their potential to predict the
individual cognitive reserve. Subjects & Methods: In 110 mild
cognitive impaired and demented subjects (age 71 ± 8 years)
with a final diagnosis of AD dementia were assessed at baseline
by mini-mental-state-examination (MMSE), FDG-PET, MRI
and CSFt-tau. Using partial correlation, we tested first for each
neuronal injury marker the correlation with MMSE, controlled
for age, gender and leukoencephalopathy. Next using multiple
regression analysis, we calculated the expected MMSE score
based on neuronal injury markers and covariates (MMSENI). The
residuals of the partial correlation for each biomarker and the
difference between MMSENI and MMSECLI were correlated with
the cognitive outcome of patients at clinical follow-up (27 ± 13
months). Results: FDG-PET correlated highly with MMSECLI (R =
-0.49, p < 0.01), whereas hippocampal atrophy in MRI (R = -0.15,
p = 0.14) and CSFt-tau (R = -0.12, p = 0.22) showed only weak correlations.
High neuronal injury relative to cognitive performance
was associated with more pronounced cognitive deterioration
at follow-up for the residuals of FDG-PET (R = -0.40, p = 0.005)
and the combined model (R = -0.43, p = 0.04). Conclusions:
The residuals in the correlation of neuronal injury in FDG-PET
and cognitive performance represent the individual cognitive
reserve in patients with AD and may allow a prediction of an
individual’s clinical course. Thus, the individual cognitive reserve
should be considered as a covariate in therapeutic trials.
Item Type: |
Conference or Workshop Item (Abstract) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Rominger, Axel Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1619-7070 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Sabine Lanz |
Date Deposited: |
07 Jun 2019 09:43 |
Last Modified: |
05 Dec 2022 15:26 |
Additional Information: |
OP-710 |
BORIS DOI: |
10.48350/126201 |
URI: |
https://boris.unibe.ch/id/eprint/126201 |
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