In vivo Imaging of Microglial Activation in Patients with Clinical Suspected Progressive Supranuclear Palsy: A 18FGE180 PET study

Sauerbeck, J.; Beyer, L.; Rohrer, G.; Sonnenfeld, S.; Nübling, G.; Höglinger, G.; Bartenstein, P.; Levin, J.; Rominger, Axel Oliver; Brendel, M. (2018). In vivo Imaging of Microglial Activation in Patients with Clinical Suspected Progressive Supranuclear Palsy: A 18FGE180 PET study. European journal of nuclear medicine and molecular imaging, 45(S1), S267-S267. Springer-Verlag

Introduction: Progressive supranuclear palsy (PSP) is a 4R-tauopathy with a severe clinical course. The pathophysiological processes are not sufficiently understood and a causal therapy for this life limiting disease is still missing. The neuropathological hallmark of PSP are accumulated tau protein fibrils that were claimed to be responsible for following neurodegeneration. Microglial activation has been shown to occur in PSP as another hallmark of the disease. Therefore, we aimed to establish in vivo imaging of microglial activity by 18kDa translocator protein (TSPO) PET. Methods: Seven patients with probable PSP according to current diagnosis criteria underwent 18FGE180 TSPO PET. All images were scaled by the global mean and standardized uptake value ratios (SUVR) were generated in brain regions typically affected in PSP. Voxel-wise differences were calculated using seven healthy individuals (HC) serving as controls. Furthermore, we compared patterns of microglial acactivity with 18F-THK5351 PET (tau/MAO-B ligand) deriving from previously imaged patients with PSP, matched for age and disease severity. Results: Significantly increased 18F-GE180 binding in PSP versus HC was found in the anterior cingulate gyrus (+22%, p < 0.001), globus pallidus (+14%, p < 0.005), and nucleus dentatus (+24%, p = 0.001). Voxel-wise microglial activation matched known regions of disease affection in PSP except for the midbrain. Contrary 18F-THK5351-PET showed increased binding predominantly in the midbrain (+19%, p < 0.001) and binding was also significantly elevated in brain regions with increased TSPO activity. Conclusion: TSPO-PET imaging in PSP patients is feasible and patterns of microglial activation correlated topologically with most brain regions known to be affected in PSP. The particularly low microglial activation in the midbrain compared to highest binding of tau/MAO-B ligands needs further investigation by specific ligands for tau and astrocytosis.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1619-7070

Publisher:

Springer-Verlag

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

07 Jun 2019 09:46

Last Modified:

07 Jun 2019 09:46

Additional Information:

E-PW081

URI:

https://boris.unibe.ch/id/eprint/126202

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